Second-trimester maternal serum invasive trophoblast antigen: a marker for Down syndrome screening.

نویسندگان

  • Raj Pandian
  • Laurence A Cole
  • Glenn E Palomaki
چکیده

Immunosuppressive Drug Monitoring. Ther Drug Monit 2002;24:59–67. 12. Novartis. Neoral C-2 monitoring: scientific evidence and clinical validation. http://www.transplantation-schweiz.ch/e/sandimmun/Scientific_Monograph. pdf (accessed June 2004). 13. Morris RG, Russ GR, Cervelli MJ, Juneja R, McDonal SP, Mathew TH. Comparison of trough, 2-hour, and limited AUC blood sampling for monitoring cyclosporine at day 7 post-renal transplantation and incidence of rejection in the first month. Ther Drug Monit 2002;24:479–86. 14. Oellerich M, Armstrong VW. Two-hour cyclosporine concentration determination: an appropriate tool to monitor neoral therapy? Ther Drug Monit 2002;24:40–6. 15. Johnston A, Chusney G, Oellerich M, Lee TD, Holt DW. Monitoring cyclosporine in blood: between assay differences at trough and 2 hour post-dose (C2). Ther Drug Monit 2003;25:167–73. 16. Strologo LD, Ponstesilli C, Rizzoni G. C2 monitoring: a reliable tool in pediatric renal transplant recipients. Transplantation 2003;76:444–5. 17. Holt DW, Johnston A, Kahan BD, Morris RG, Oellerich M, Shaw LM. New approaches to cyclosporine monitoring raise further concerns about analytical techniques. Clin Chem 2000;46:872–4. 18. Abbott Laboratories. TDxFLx cyclosporine monoclonal whole blood. Package insert 9797-60 E 34-0060/R7. Abbott Park, IL: Abbott Laboratories, 2001: 1–6.

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Maternal serum invasive trophoblast antigen and first-trimester Down syndrome screening.

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BACKGROUND Down syndrome screening is commonly performed in the US using maternal age and three or four second-trimester maternal serum markers that can identify up to 75% of affected pregnancies by offering diagnostic studies to 5% of women. Invasive trophoblast antigen [ITA; hyperglycosylated human chorionic gonadotropin (hCG)] is a promising marker that can be measured in urine or serum in t...

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Hyperglycosylated human chorionic gonadotropin (invasive trophoblast antigen) immunoassay: A new basis for gestational Down syndrome screening.

BACKGROUND Serum human chorionic gonadotropin (hCG) and hCG free beta-subunit tests are used in combination with unconjugated estriol and alpha-fetoprotein in the triple screen test, and with the addition of inhibin-A in the quadruple marker test for detecting Down syndrome in the second trimester of pregnancy. These tests have a limited detection rate for Down syndrome: approximately 40% for h...

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RELATIONSHIP BETWEEN THE SERUM LEVELS OF FOLIC ACID WITH THE RESULTS OF FIRST TRIMESTER DOWN SYNDROME SCREENING METHODS AND FETAL KARYOTYPE IN HIGH RISK PREGNANT WOMEN REFERRING TO THE ALZAHRA EDUCATIONAL HOSPITAL OF TABRIZ

Background & Aims: To investigate associations between serum levels of folic acid with the results of the first trimester Down syndrome screening methods and fetal karyotype in high-risk pregnant women. Materials & Methods: In this cross-sectional study, serum levels of folic acid in 232 high risk pregnant women were measured using ELISA method and Down syndrome screening was done using karyot...

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Evaluation of cell-free fetal DNA as a second-trimester maternal serum marker of Down syndrome pregnancy.

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عنوان ژورنال:
  • Clinical chemistry

دوره 50 8  شماره 

صفحات  -

تاریخ انتشار 2004